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Is Alzheimer’s Disease Genetic?
Yes, genetics can influence the development of Alzheimer’s, and it is linked to the early onset of the disease. However, multiple genes influence whether someone develops Alzheimer’s disease, and these […]
Yes, genetics can influence the development of Alzheimer’s, and it is linked to the early onset of the disease. However, multiple genes influence whether someone develops Alzheimer’s disease, and these genetic instances account for less than 1% of cases. Risk genes and deterministic genes determine whether someone develops a disease, and although there are Alzheimer’s genes found in both categories, identified cases of Alzheimer’s associated with genetics are attributed to deterministic genes. Additionally, many people who develop Alzheimer’s lack any previous family history of the disease.
Sometimes, genetic mutations can cause early-onset Alzheimer’s, resulting in what is known as early-onset familial Alzheimer’s disease. Mutations in the PSEN1, PSEN2, and APP genes are common in these cases. Early onset may also occur in cases with genetic changes that have yet to be identified. It is important to note that although genetics can increase the likelihood of developing Alzheimer’s, environmental and lifestyle factors can also exacerbate this likelihood.
While there is a genetic component involved in the development of Alzheimer’s disease, it is one of many factors involved rather than being the sole cause of the disease. It is crucial to understand both the genetic and non-genetic factors contributing to Alzheimer’s to develop appropriate preventative measures, as well as potential treatments. Ultimately, ongoing research in these areas is necessary for great insight into how to manage and prevent the disease in the future.
Sources
“Alzheimer’s disease.” Medline Plus. Retrieved from https://medlineplus.gov/genetics/condition/alzheimers-disease/#causes
“Alzheimer’s disease genetics fact sheet.” National Institute on Aging. Retrieved from https://www.nia.nih.gov/health/alzheimers-causes-and-risk-factors/alzheimers-disease-genetics-fact-sheet
“What are the causes and risk factors of Alzheimer’s and other dementias?” Alzheimer’s Association. Retrieved from https://www.alz.org/alzheimers-dementia/what-is-alzheimers/causes-and-risk-factors
